phd defenses.

aqueous sequestration and solid-phase separation of actinyl ions with pamam dendrimers

abstract: nuclear energy is a sustainable baseload power source with low life cycle carbon emissions, and no emissions during power plant operations. research into new separatory schemes and technology to reprocess used nuclear fuel (unf) can further improve carbon emissions and the efficiency of the nuclear fuel cycle. improved aqueous separatory and extraction agents have the additional benefit of making the use of radionuclides safer with their ability to carefully segregate selected materials from environments such as natural bodies of water or waste streams.

bioorthogonal cyclopropenones for biomolecule ligation and reaction development

abstract: bioorthogonal chemistry enables researchers to study biomolecules in their native environments without perturbing endogenous cellular processes. over the past two decades, significant strides have been made in developing new, and refining existing, bioorthogonal reactions. the continuously expanding toolbox has opened avenues for tackling increasingly complex biological questions. despite these advances, limitations remain.

fluorescent teixobactin probes

abstract: antibiotic resistance persists as serious threat against our ability to treat drug resistant infections. in 2016, teixobactin, a new antimicrobial peptide, was reported to kill gram-positive pathogens without detectable resistance, a remarkable property that antibiotics lack. mechanistic studies have shown that teixobactin binds to cell wall precursors, resulting in cellular lysis of bacteria. however, the cellular localization of teixobactin has not been characterized, and doing so would require a fluorescent teixobactin analogue.

global observations of oceanic alkyl nitrates and dimethyl sulfide during the nasa atmospheric tomography mission (atom)

abstract:
oceanic trace gases were measured onboard the nasa dc-8 flying laboratory during the nasa atmospheric tomography field campaign with the intent to examine the spatial and temporal fluctuations to the global distribution of these species, as well as establish a dataset of global background levels for future use in the validation of satellites and the constraint of chemical transport models. airborne in situ measurements of vocs were obtained via the uc irvine whole air sampler (was) system and analyzed with gas chromatography/mass spectrometry. 

synthetic approaches to the a74528 and enterocin polyketides and catalytic asymmetric radical–polar crossover reactions

abstract:

my thesis defense will detail the new methods in total synthesis and catalysis that we have developed during my time in the pronin lab. specifically, i will focus on the strategies towards cyclopropane activation and alkyl-cobalt(iv) catalysis that we have employed to access novel catalytic asymmetric reaction manifolds and challenging polyketide scaffolds. our efforts in catalysis have culminated in the development of the first catalytic asymmetric hydrogen-atom-transfer-initiated alkene hydrofunctionalization.

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